New analysis of the comparative diagnostic performances of five different eGFR equations: The revised 2021 CKD-EPI eGFR, and the four older equations

Purpose: In 2021, the CKD-EPI-creatinine and CKD-EPI-creatinine-cystatin-C combined equations were revised again by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) National Institute of Diabetes & Digestive Diseases (NIDDK) it was reported that its accuracy increased. The main object this study is to compare diagnostic performance 2009 CKD-EPI eGFRcr, 2012 eGFRCysC, eGFRcr-CysC, MDRD, 2021 provide a better estimation.
 Materials Methods: design prospective. sample consisted 111 CKD patients 35 healthy individuals who applied nephrology clinic. All participants evaluated nephrologist. divided into groups according their KDIGO classification. Five variables used: age, race, gender, serum creatinine, cystatin-C.
 Results: eGFR cystatin-C out performed existing in terms accuracy, specificity, sensitivity (AUC:0.988). Furthermore, when both creatinine are included an equation, consistently improves values over formulas containing only (2009CKD-EPI eGFRcr AUC:0.953, 2012CKD-EPI eGFRcr-CysC AUC: 0.985, 2021CKD-EPI AUC:0.954, MDRD 0.953, 0.985).
 Conclusion: new formula has not been confirmed be superior other ability estimate values, particularly at higher levels chronic kidney disease. When compared with equations, eGFRCysC had specificity sensitivity. Combined blood tests than creatinine. Our results can help inform which use for estimation renal function screening.